Induced Pluripotent Stem Cell Derived Exosome Treatment for Cardiac Regeneration

Published 2020-10-05

A recent study published in the journal Science Translational Medicine provided evidence of cardiac regenerative properties from cardiac cell derived exosomes. In the study conducted at the University of Alabama at Birmingham, researchers developed exosomes from cardiomyocytes, cardiac smooth muscle cells and endothelial cells which were generated from human induced pluripotent stem cells. In a preclinical pig cardiac injury model, the exosome treatment was then compared to a treatment with the induced pluripotent stem cell derived cardiac cells. Results indicated a similar benefit from the exosome treatment compared to that of the cardiac cell treatment.