Stem Cell Gene Editing Advances
Researchers from Arizona State University's biomedical engineering department, led by Dr. David Brafman developed an improved platform for induced pluripotent Stem Cell gene editing. Traditionally the efficiency of the gene editing tool CRISPR for Stem Cells had a low efficiency (5-10%). The updated CRISPR technology employs a method called 'Tranisent Reporter for Editing Enrichment' (TREE). TREE cuts single rather than conventional CRISPR double strands of DNA. The new methodology may have editing success close to 90%, providing a vast improvement over conventional CRISPR editing rates. This may provide for an efficient platform for induced pluripotent Stem Cell gene editing as a therapeutic tool. The study is published in the January 30th, 2020 edition of Stem Cell Reports.
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